Salman MS, Sharpe JA, Eizenman M, Lillakas L, To T, Westall C, Steinbach MJ, Dennis M. Saccades in children with spina bifida and Chiari type II malformation.
Neurology. 2005 Jun 28;64(12):2098-101.
BACKGROUND: Saccades are essential for optimal visual function. Chiari type II malformation (CII) is a congenital anomaly of the cerebellum and brainstem, associated with spina bifida.
OBJECTIVE: To investigate the effects of CII on saccades and correlate saccadic parameters with brain MRI measurements.
METHODS: Saccades were recorded in 21 participants with CII, aged 8 to 19, using an infrared eye tracker. Thirty-nine typically developing children served as controls. Participants made saccades to horizontal and vertical target steps. Nineteen participants with CII had MRI. Regression analyses were used to investigate the effects of spinal lesion level, number of shunt revisions, presence of nystagmus, and midsagittal MRI measurements on saccades.
RESULTS: Saccadic amplitude gains, asymptotic peak velocities, and latencies did not differ between the control and CII groups (p > 0.01). No significant differences were found between saccadic gains, asymptotic peak velocities or latencies, and spinal lesion level, number of shunt revisions, presence of nystagmus, or MRI measurements.
CONCLUSIONS: Saccades were normal in most participants with Chiari II malformation (CII). Neural coding of saccades is robust and is typically not affected by the anatomic deformity of CII.
PMID: 15985580
Showing posts with label Ocular. Show all posts
Showing posts with label Ocular. Show all posts
Tuesday, July 31, 2007
Degree of tectal beaking correlates to the presence of nystagmus in children with Chiari II malformation
Tubbs RS, Soleau S, Custis J, Wellons JC, Blount JP, Oakes WJ. Degree of tectal beaking correlates to the presence of nystagmus in children with Chiari II malformation. Child's Nervous System. 2004 Jul;20(7):459-61. Epub 2004 Apr 2.
INTRODUCTION: Tectal beaking is a common finding in children born with a myelomeningocele. Quantitation of the presence or absence of this finding correlated with normal or abnormal eye movements is lacking in the medical literature.
MATERIALS AND METHODS: We prospectively evaluated 50 children in our multidisciplinary spina bifida clinic. Each child was observed for the presence or absence of nystagmus at rest or with extraocular movement. Grades of nystagmus and severity of tectal beaking (Types I-III) on MRI were then correlated.
RESULTS: Overwhelmingly, children with greater dysmorphology of the mesencephalic tectum were most likely to have nystagmus. Higher grades of nystagmus were associated with Type III tectal beaking.
CONCLUSIONS: We have demonstrated that there is a correlation between the presence and severity of nystagmus and the severity of tectal beaking and have quantified this association in patients with the Chiari II malformation. This information may act as a guide in predicting which children with the Chiari II malformation will have significant nystagmus. These data may aid the clinician in the interpretation of oculomotor abnormalities in this cohort of patients.
PMID: 15060837
INTRODUCTION: Tectal beaking is a common finding in children born with a myelomeningocele. Quantitation of the presence or absence of this finding correlated with normal or abnormal eye movements is lacking in the medical literature.
MATERIALS AND METHODS: We prospectively evaluated 50 children in our multidisciplinary spina bifida clinic. Each child was observed for the presence or absence of nystagmus at rest or with extraocular movement. Grades of nystagmus and severity of tectal beaking (Types I-III) on MRI were then correlated.
RESULTS: Overwhelmingly, children with greater dysmorphology of the mesencephalic tectum were most likely to have nystagmus. Higher grades of nystagmus were associated with Type III tectal beaking.
CONCLUSIONS: We have demonstrated that there is a correlation between the presence and severity of nystagmus and the severity of tectal beaking and have quantified this association in patients with the Chiari II malformation. This information may act as a guide in predicting which children with the Chiari II malformation will have significant nystagmus. These data may aid the clinician in the interpretation of oculomotor abnormalities in this cohort of patients.
PMID: 15060837
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