McLone DG. The etiology of neural tube defects: the role of folic acid.
Child's Nervous System. 2003 Aug;19(7-8):537-9. Epub 2003 Aug 12.
DISCUSSION: While the cause of neural tube defects in humans is considered to be multifactorial, it is apparent that folic acid can prevent 70% of open neural tube defects. Even in laboratory animals with known genetic defects, folic acid can prevent the genetic expression.
CONCLUSION: While some of the metabolic pathways for folic acid are known, the true effects of folic acid on closure of the neural tube have yet to be discovered.
PMID: 12920544
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