tag:blogger.com,1999:blog-1435528494942943882024-03-12T22:41:17.932-05:00Spina Bifida Research BibliographyA review of selected peer-reviewed bio-medical journals citations related to spina bifida myelomeningocele.lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.comBlogger452125tag:blogger.com,1999:blog-143552849494294388.post-90967480325750694282017-05-10T14:12:00.000-05:002017-05-10T14:12:17.633-05:00<div class="title">
Mummareddy N, Dewan MC, Mercier MR, Naftel RP, Wellons JC 3rd, Bonfield CM. (2017) <a href="https://www.ncbi.nlm.nih.gov/pubmed/28452655" ref="ordinalpos=17&ncbi_uid=28452655&link_uid=28452655&linksrc=docsum_title">Scoliosis in myelomeningocele: epidemiology, management, and functional outcome.</a></div>
<div class="supp">
<div class="desc">
<span class="jrnl" title="Journal of neurosurgery. Pediatrics">Journal of Neurosurgery. Pediatrics</span>. 2017 Apr 28:1-10. doi: 10.3171/2017.2.PEDS16641. [Epub ahead of print] PMID: 28452655</div>
<div class="desc">
</div>
<h3>
Abstract</h3>
<div>
<abstracttext>OBJECTIVE The authors aimed to provide an updated and consolidated report on the epidemiology, management, and functional outcome of cases of myelomeningocele (MMC) in patients with scoliosis. METHODS A comprehensive literature search was performed using MEDLINE, Embase, Google Scholar, and the Cochrane Database of Systematic Reviews on cases of MMC in patients with scoliosis between 1980 and 2016. The initial search yielded 670 reports. After removing duplicates and applying inclusion criteria, we included 32 full-text original articles in this study. RESULTS Pooled statistical analysis of the included articles revealed the prevalence of scoliosis in MMC patients to be 53% (95% CI 0.42-0.64). Slightly more females (56%) are affected with both MMC and scoliosis than males. Motor level appears to be a significant predictor of prevalence, but not severity, of scoliosis in MMC patients. Treatment options for these patients include tethered cord release (TCR) and fusion surgeries. Curvature improvement and stabilization after TCR may be limited to patients with milder (< 50°) curves. Meanwhile, more aggressive fusion procedures such as a combined anterior-posterior approach may result in more favorable long-term scoliosis correction, albeit with greater complication rates. Quality of life metrics including ambulatory status and sitting stability are influenced by motor level of the lesion as well as the degree of the scoliosis curvature. CONCLUSIONS Scoliosis is among the most common and challenging comorbidities from which patients with MMC suffer. Although important epidemiological and management trends are evident, larger, prospective studies are needed to discover ways to more accurately counsel and more optimally treat these patients.</abstracttext></div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com1tag:blogger.com,1999:blog-143552849494294388.post-29127416175039337352017-05-10T14:10:00.000-05:002017-05-10T14:10:10.312-05:00<div class="title">
Polfuss M, Bandini LG, Sawin KJ. (2017) <a href="https://www.ncbi.nlm.nih.gov/pubmed/28455677" ref="ordinalpos=16&ncbi_uid=28455677&link_uid=28455677&linksrc=docsum_title">Obesity Prevention for Individuals with <b>Spina Bifida</b>.</a></div>
<div class="supp">
<div class="desc">
<span class="jrnl" title="Current obesity reports">Current Obesity Reports</span>. 2017 Apr 28. doi: 10.1007/s13679-017-0254-y. [Epub ahead of print] Review. PMID: 28455677</div>
<div class="desc">
</div>
<h3>
Abstract</h3>
<div>
<h4>
PURPOSE OF REVIEW: </h4>
<abstracttext label="PURPOSE OF REVIEW" nlmcategory="OBJECTIVE">Obesity is a common comorbidity in individuals with <span class="highlight">spina bifida</span>. Carrying excess weight exacerbates the inherent health challenges associated with <span class="highlight">spina bifida</span>, impedes the individual's ability to self-manage their condition, and creates further challenges for family members and caregivers. This manuscript provides a narrative review of key issues for understanding and prevention of obesity in persons with <span class="highlight">spina bifida</span> within the context of the social ecological model.</abstracttext><br />
<h4>
RECENT FINDINGS: </h4>
<abstracttext label="RECENT FINDINGS" nlmcategory="RESULTS">Specific variables related to obesity and <span class="highlight">spina bifida</span> include individual factors (i.e., body composition and measurement issues, energy needs, eating patterns, physical activity, and sedentary activity) family factors (i.e., parenting/family, peers), community factors (i.e., culture, built environment, healthcare and healthcare providers, and school), and societal factors (i.e., policy issues). Due to the complex etiology of obesity and its increased prevalence in individuals with <span class="highlight">spina bifida</span>, it is critical to initiate prevention efforts early with a multifactorial approach for this at-risk population. Increased research is warranted to support these efforts.</abstracttext></div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-76759399052776266912017-05-10T14:07:00.000-05:002017-05-10T14:07:48.104-05:00<div class="title">
Ware AL, Kulesz PA, Juranek J, Cirino PT, Fletcher JM. (2017) <a href="https://www.ncbi.nlm.nih.gov/pubmed/28206781" ref="ordinalpos=14&ncbi_uid=28206781&link_uid=28206781&linksrc=docsum_title">Cognitive control and associated neural correlates in adults with <b>spina bifida</b> myelomeningocele.</a> <span class="jrnl" title="Neuropsychology">Neuropsychology</span>. 2017 May;31(4):411-423. doi: 10.1037/neu0000350. Epub 2017 Feb 16. PMID: 28206781</div>
<div class="title">
</div>
<h3>
Abstract</h3>
<div>
<h4>
OBJECTIVE: </h4>
<abstracttext label="OBJECTIVE" nlmcategory="OBJECTIVE">Accelerated aging can occur in adult survivors of neurodevelopmental disorders, but has been narrowly studied in <span class="highlight">spina bifida</span> myelomeningocele (SBM). Since discrete aspects of cognitive control and related neural network macrostructure deteriorate in normal aging, the specificity and trajectory of cognition and neuropathology incurred across adulthood in SBM were examined.</abstracttext><br />
<h4>
METHOD: </h4>
<abstracttext label="METHOD" nlmcategory="METHODS">Adults (N = 120) with and without SBM completed working memory span and manipulation tasks, and an inhibitory control task. A subset (n = 53) underwent structural MRI. Effects of group, age, and their interaction on performance and select gray matter volumes were examined.</abstracttext><br />
<h4>
RESULTS: </h4>
<abstracttext label="RESULTS" nlmcategory="RESULTS">Adults with SBM had significantly poorer working memory accuracy and overall inhibitory control performance than typical peers. Age negatively predicted inhibitory control. Group × Age significantly interacted on span accuracy; advanced age related to diminished performance in typical adults, but not in adults with SBM. SBM related to disproportionately enlarged cortical and putamen and reduced hippocampus volumes. Group × Age significantly interacted on cortical, but not subcortical gray matter volumes. Dorsolateral prefrontal, hippocampus, and putamen volumes negatively correlated with cognitive performance.</abstracttext><br />
<h4>
CONCLUSIONS: </h4>
<abstracttext label="CONCLUSIONS" nlmcategory="CONCLUSIONS">Supporting previous literature, current findings elucidated a profile of executive impairment in SBM that was maintained in a parallel maturational trajectory to typical aging. Accelerated aging in cognitive control or subcortical gray matter was not supported in SBM. However, reductions in anterior and posterior cortical regions were exacerbated in older adults with SBM compared with typical peers. Overall results supported persistent anomalous neurodevelopmental maturation across the life span in SBM that related to diminished cognitive control. (PsycINFO Database Record</abstracttext><br />
<div class="copyright">
(c) 2017 APA, all rights reserved).</div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-87302589000665781602017-05-10T13:59:00.002-05:002017-05-10T13:59:43.178-05:00<div class="title">
Chan YY, Sandlin SK, Kurzrock EA. (2017) <a href="https://www.ncbi.nlm.nih.gov/pubmed/28285380" ref="ordinalpos=12&ncbi_uid=28285380&link_uid=28285380&linksrc=docsum_title">Urological Outcomes of Myelomeningocele and Lipomeningocele.</a> <span class="jrnl" title="Current urology reports"><em>Current Urological Reports</em></span>. 2017 May;18(5):35. doi: 10.1007/s11934-017-0684-9. Review.</div>
<div class="title">
</div>
<h3>
Abstract</h3>
<div>
<h4>
PURPOSE OF REVIEW: </h4>
<abstracttext label="PURPOSE OF REVIEW" nlmcategory="OBJECTIVE"><span class="highlight">Spina bifida</span> is caused by incomplete neural tube closure during the first trimester. This condition may lead to bowel and bladder dysfunction as well as truncal weakness and motor anomalies. Presentations vary between myelomeningoceles and lipomeningoceles and may result in different outcomes. This review seeks to explore our current understanding of the variations in outcomes between individuals with myelomeningocele and lipomeningocele.</abstracttext><br />
<h4>
RECENT FINDINGS: </h4>
<abstracttext label="RECENT FINDINGS" nlmcategory="RESULTS">Prenatal intervention has become a standard of care for prenatal diagnoses of myelomeningocele and has been shown to reduce shunt placement and improve motor skills. However, urological benefit from early intervention remains to be seen. Early surgical repair, however, may be beneficial for patients with lipomeningocele. Literature on the urological outcomes of patients with myelomeningocele and lipomeningocele is lacking. Further research is needed to better elucidate differences in long-term urological outcomes between these two pathologies.</abstracttext></div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-38847333260208175192017-05-10T13:57:00.001-05:002017-05-10T13:57:21.653-05:00<div class="title">
De la Torre GG, Martin A, Cervantes E, Guil R, Mestre JM. (2017) <a href="https://www.ncbi.nlm.nih.gov/pubmed/27868580" ref="ordinalpos=1&ncbi_uid=27868580&link_uid=27868580&linksrc=docsum_title">Attention lapses in children with <b>spina bifida</b> and hydrocephalus and children with attention-deficit/hyperactivity disorder.</a> <span class="st"><em>Journal of Clinical</em> and Experimental <em>Neuropsychology</em></span>. 2017 Aug;39(6):563-573. doi: 10.1080/13803395.2016.1249828.</div>
<div class="title">
</div>
<h3>
Abstract</h3>
<div>
<abstracttext>Attentional lapses are usually defined as temporary and often brief shifts of attention away from some primary task to unrelated internal information processing. This study addressed the incidence of attention lapses and differences in attentional functioning in 30 children with attention-deficit/hyperactivity disorder (ADHD), 26 healthy children, and 29 children with <span class="highlight">spina bifida</span> myelomeningocele and hydrocephalus (SBH). Assessments were conducted using computerized tonic and phasic attention tests, the Symbol Digit Modalities Test (SDMT), and the Trail Making Test Form B (TMT-B). The group with SBH differed from normal controls on cognitive measures of attention and executive functions. The ADHD group obtained lower scores than the SBH group and healthy children. ANOVA results showed that there was an effect of shunt revisions and shunt-related infections on neuropsychological performance. Lapses of attention together with reaction time may thus represent important factors for the understanding of cognitive deficits in SBH.</abstracttext></div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-22433181964030873482015-05-11T14:11:00.001-05:002015-05-11T14:11:34.051-05:00Update on Urological Management of Spina Bifida from Prenatal Diagnosis to Adulthood.<div class="title">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/25839383"></a></div>
<div class="desc">
Snow-Lisy DC, Yerkes EB, Cheng EY. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25839383">Update on Urological Management of <b>Spina Bifida</b> from Prenatal Diagnosis to Adulthood.</a></div>
<span class="jrnl" title="The Journal of urology">J Urol</span>. 2015 Apr 1. pii: S0022-5347(15)03647-2. doi: 10.1016/j.juro.2015.03.107<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
PURPOSE: </h4>
We review the current literature regarding urological management of <span class="highlight">spina bifida</span> from prenatal diagnosis to adulthood.<br />
<h4>
MATERIALS AND METHODS: </h4>
We searched MEDLINE, EMBASE and PubMed for English articles published through December 2014 using search terms "<span class="highlight">spina bifida</span>," "<span class="highlight">spinal dysraphism</span>"
and "bladder." Based on review of titles and abstracts, 437 of 1,869
articles were identified as addressing topics related to open <span class="highlight">spina bifida</span> in pediatric patients, or long-term or quality of life outcomes in adults with <span class="highlight">spina bifida</span>. We summarize this literature to inform clinical guidelines and create a framework for disease management.<br />
<h4>
RESULTS: </h4>
The birth prevalence of <span class="highlight">spina bifida</span>
in the United States has recently plateaued at approximately 30 per
100,000. With improved management more individuals are surviving to
adulthood, with an economic impact of $319,000 during the lifetime of an
individual with <span class="highlight">spina bifida</span>. Recent advances in prenatal surgery have demonstrated that prenatal closure of <span class="highlight">spina bifida</span>
is possible. To assess safety and efficacy, the National Institutes of
Health sponsored MOMS (Management of Myelomeningocele Study) was
undertaken, in which subjects were randomized to prenatal or postnatal
closure. Until the urological results of this trial are published, the
impact of prenatal intervention on future bladder function remains
unclear. Controversy continues regarding the optimal use and timing of
urodynamic studies, and the indications for initiation of clean
intermittent catheterization and anticholinergics in infants and
children. Many favor expectant management, while others argue for a more
proactive approach. Based on the current literature, both approaches
appear to protect the child from renal injury, although delayed
intervention may increase rates of bladder augmentation. The current
literature regarding this topic is difficult to interpret and compare
due to heterogeneity of patient populations, variable outcome measures
and lack of reporting of quality of life outcomes. Surgical intervention
is indicated for those at risk for renal deterioration and/or is
considered for children who fail to achieve satisfactory continence with
medical management. Traditionally surgery concentrates on 3 areas, ie
bladder and bladder neck, and creation of catheterizable channels. For
those with a hostile bladder enterocystoplasty remains the gold standard
for bladder augmentation, although use of bowel for augmentation
remains suboptimal due to secondary complications, including increased
risk of infections, metabolic abnormalities, neoplastic transformation
and risk of life threatening perforation. Recent advances in tissue
engineering technology may provide an alternative to traditional
augmentation. However, recent results from phase II trials using current
techniques to augment the bladder with engineered bladder tissue are
disappointing. Catheterizable channels to the bladder and ascending
colon further facilitate continence measures and promote independent
care. While surgical reconstruction is clearly successful in improving
continence, recent outcome studies have questioned the true impact of
this type of surgery on quality of life. With improved survival
transitional care issues, including health related independence, sexual
health needs and development of a support system, are increasingly
important. Transitional care remains a significant issue for which few
public health measures are being quantitatively evaluated.<br />
<h4>
CONCLUSIONS: </h4>
Despite consensus regarding early urological involvement in the care of patients with <span class="highlight">spina bifida</span>,
controversy remains regarding optimal management. Major reconstructive
urological surgeries still have a major role in the management of these
cases to protect the upper urinary tract and to achieve continence.
However, future studies are needed to better clarify the true impact on
quality of life that these interventions have on patients and their
families. Transition of urological care to adulthood remains a major
avenue for improvement in disease management.<br />
Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.</div>
</div>
<div class="keywords">
<h4>
KEYWORDS: </h4>
disease management; meningomyelocele; <span class="highlight">spinal dysraphism</span>; urinary bladder</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-17171289620004725592015-05-11T14:09:00.003-05:002015-05-11T14:09:58.737-05:00<div class="title">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/25244941"></a></div>
<div class="desc">
Lennon JM, Klages KL, Amaro CM, Murray CB, Holmbeck GN. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25244941">Longitudinal study of neuropsychological functioning and internalizing symptoms in youth with <b>spina bifida</b>: social competence as a mediator.</a></div>
<span class="jrnl" title="Journal of pediatric psychology">J Pediatr Psychol</span>. 2015 Apr;40(3):336-48. doi: 10.1093/jpepsy/jsu075.<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
OBJECTIVE: </h4>
To
examine the longitudinal relationship between neuropsychological
functioning and internalizing symptoms, as mediated by social competence
in youth with <span class="highlight">spina bifida</span> (SB).<br />
<h4>
METHODS: </h4>
A
total of 111 youth (aged 8-15 years, M = 11.37) with SB, their parents,
and teachers completed questionnaires regarding attention, social
competence, and internalizing symptoms. Youth also completed a battery
of neuropsychological tests.<br />
<h4>
RESULTS: </h4>
An
indirect-only mediation model revealed that social competence mediated
the relation between neuropsychological functioning and subsequent
levels of teacher-reported internalizing symptoms, but not parent or
youth report of internalizing symptoms. Specifically, better
neuropsychological functioning was associated with better social
competence, which, in turn, predicted fewer internalizing symptoms 2
years later.<br />
<h4>
CONCLUSIONS: </h4>
Youth
with SB with lower levels of neuropsychological functioning may be at
risk for poorer social competence and, as a result, greater
internalizing symptoms. Interventions that promote social competence,
while being sensitive to cognitive capacities, could potentially
alleviate or prevent internalizing symptoms in these youth.<br />
©
The Author 2014. Published by Oxford University Press on behalf of the
Society of Pediatric Psychology. All rights reserved. For permissions,
please e-mail: journals.permissions@oup.com.</div>
</div>
<div class="keywords">
<h4>
KEYWORDS: </h4>
internalizing symptoms; neuropsychological functioning; social competence; <span class="highlight">spina bifida</span></div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-56618724660610845132015-05-11T14:08:00.003-05:002015-05-11T14:08:46.580-05:00Observed differences in social behaviors exhibited in peer interactions between youth with spina bifida and their peers: neuropsychological correlates.<div class="title">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/25427551"></a></div>
<div class="desc">
Holbein CE, Lennon JM, Kolbuck VD, Zebracki K, Roache CR, Holmbeck GN. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25427551">Observed differences in social behaviors exhibited in peer interactions between youth with <b>spina bifida</b> and their peers: neuropsychological correlates.</a></div>
<span class="jrnl" title="Journal of pediatric psychology">J Pediatr Psychol</span>. 2015 Apr;40(3):320-35. doi: 10.1093/jpepsy/jsu101.<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
OBJECTIVE: </h4>
To identify differences in social behaviors in observed peer interactions between children with <span class="highlight">spina bifida</span> (SB) and peers, and to examine neuropsychological correlates of these differences.<br />
<h4>
METHOD: </h4>
A
total of 100 youth (aged 8-15 years) with SB and peers participated in
video-recorded interaction tasks, which were coded for interaction
style, affect, and collaboration. Children with SB also completed a
neuropsychological test battery.<br />
<h4>
RESULTS: </h4>
Children
with SB demonstrated less adaptive social behaviors in peer
interactions, particularly within the interaction style domain.
Observational items found to be different between children with SB and
their peers were best predicted by social language and attention
abilities.<br />
<h4>
CONCLUSIONS: </h4>
Children
with SB exhibit a less adaptive interaction style and lower levels of
social dominance but are comparable with typically developing peers on
other social behaviors. The observed group differences may have a
neuropsychological basis.<br />
© The Author 2014.
Published by Oxford University Press on behalf of the Society of
Pediatric Psychology. All rights reserved. For permissions, please
e-mail: journals.permissions@oup.com.</div>
</div>
<div class="keywords">
<h4>
KEYWORDS: </h4>
neuropsychological functioning; observational methods; peer relationships; social competence; <span class="highlight">spina bifida</span></div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-1504350934031530742015-05-11T14:06:00.003-05:002015-05-11T14:06:56.515-05:00Postshunt lateral ventricular volume, white matter integrity, and intellectual outcomes in spina bifida and hydrocephalus.<div class="title">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/25634821"></a></div>
<div class="desc">
Williams VJ, Juranek J, Stuebing KK, Cirino PT, Dennis M, Bowman RM, Blaser S, Kramer LA, Fletcher JM. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25634821">Postshunt lateral ventricular volume, white matter integrity, and intellectual outcomes in <b>spina bifida</b> and hydrocephalus.</a></div>
<span class="jrnl" title="Journal of neurosurgery. Pediatrics">J Neurosurg Pediatr</span>. 2015 Apr;15(4):410-9. doi: 10.3171/2014.10.PEDS13644<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
OBJECT
No previous reports exist that have evaluated the relationships of
white matter (WM) integrity with the number of shunt revisions,
ventricular volume after shunting, and cognition in medically stable
children who have <span class="highlight">spina bifida</span>
and hydrocephalus (SBH). The authors hypothesized that enlarged
ventricles and a greater number of shunt revisions decrease WM integrity
in children. METHODS In total, 80 children (mean age 13.7 years) who
had SBH underwent MRI and IQ testing. Probabilistic diffusion
tractography was performed to determine mean diffusion tensor imaging
(DTI) metrics along the frontal and parietal tectocortical pathways. The
DTI metrics were evaluated for significant correlation with a composite
IQ measure and with the total number of shunt revisions and the total
lateral ventricular volume obtained through semiautomated parcellation
of T1-weighted MRI scans. RESULTS An enlargement in total lateral
ventricle volume and an increase in the number of shunt revisions were
both associated with higher fractional anisotropy (FA) and with lower
radial diffusivity (RD) along both frontal and parietal tectocortical
pathways. Children who had not undergone a shunt revision had on average
a greater lateral ventricle volume and higher FA and lower RD along
frontal and parietal pathways than those who had undergone multiple
shunt revisions. The mean DTI metrics along parietal pathways predicted
IQ scores, but intellectual ability was not significantly correlated
with ventricular volume or with the number of lifetime shunt revisions.
CONCLUSIONS Significant changes in DTI metrics were observed as a
function of ventricular volume. An increased lateral ventricle volume
was associated with elevated FA and decreased RD. Given that the
participants were medically stable at the time of the MRI examination,
the results suggested that those who have enlarged ventricles show a DTI
pattern consistent with axonal compression due to increased
intracranial pressure (ICP) in attenuated hydrocephalus. Although
limited by a cross-sectional design, the study's findings suggest that
DTI metrics may serve as sensitive indicators for chronic, mild
hydrocephalus in the absence of overt clinical symptoms due to increased
ICP. Having enlarged ventricles and undergoing multiple shunt revisions
did not affect intellectual ability in children with SBH. </div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-80604321383433031592015-05-11T14:05:00.000-05:002015-05-11T14:05:00.741-05:00Follow-up of the neuro-urological patient: a systematic review.<div class="title">
</div>
<div class="supp">
<div class="desc">
Averbeck MA, Madersbacher H. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25891319">Follow-up of the neuro-urological patient: a systematic review.</a></div>
<div class="details">
<span class="jrnl" title="BJU international">BJU Int</span>. 2015 Apr;115 Suppl 6:39-46. doi: 10.1111/bju.13084.</div>
<div class="details">
<br /></div>
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
OBJECTIVES: </h4>
To
systematically review the long-term urological follow-up strategies for
patients with neurogenic lower urinary tract dysfunction (NLUTD),
focusing on three main groups of neurological diseases: (i) <span class="highlight">spinal</span> cord injuries, (ii) <span class="highlight">spinal dysraphism</span>, and (iii) multiple sclerosis.<br />
<h4>
PATIENTS AND METHODS: </h4>
Data
acquisition comprised electronic search on the Medical Literature
Analysis and Retrieval System Online (MEDLINE) database and the EMBASE
database in August 2014 to retrieve English language studies. MEDLINE
and EMBASE search included the following medical subject heading (MeSH)
terms: (i) neurogenic bladder and (ii) neurogenic bladder dysfunction.
Each of these terms was crossed with (i) long-term care and (ii)
long-term surveillance. Only studies related to NLUTD and urological
follow-up were included. Studies were also identified by hand search of
reference lists and review articles.<br />
<h4>
RESULTS: </h4>
Initial
records identified through database searching included 265 articles. In
all, 23 articles were included in the quantitative synthesis. The
proposed time schedule of investigations as well as the amount and type
of investigation were different according to specific neurological
lesions. They depend on the dysfunctional pattern of the lower urinary
tract (LUT) and its risk profile. However, there is a lack of
high-evidence level studies to support an optimal long-term follow-up
protocol.<br />
<h4>
CONCLUSIONS: </h4>
The
goal of neuro-urological management is the best possible preservation
of upper urinary tract (UUT) and LUT function in relation to the
individual neurological disorder. Regular and risk adapted controls
('urochecks') allow detection of risk-factors in time before
irreversible changes of the LUT and UUT have occurred. With risk- and
patient-oriented lifelong regular urological care an optimised quality
of life and life-expectancy can be achieved, although there is a
complete lack of high-evidence level studies on this topic.<br />
© 2015 The Authors. BJU International © 2015 BJU International.</div>
</div>
<div class="details">
<br /></div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-63080679033954869462015-05-11T14:03:00.000-05:002015-05-11T14:03:07.985-05:00Syrinx location and size according to etiology: identification of Chiari-associated syrinx.<span></span><br />
<div class="title">
</div>
<div class="desc">
Strahle J, Muraszko KM, Garton HJ, Smith BW, Starr J, Kapurch JR 2nd, Maher CO. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25837888">Syrinx location and size according to etiology: identification of Chiari-associated syrinx.</a></div>
<span class="jrnl" title="Journal of neurosurgery. Pediatrics">J Neurosurg Pediatr</span>. 2015 Apr 3:1-9.<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
OBJECT Syrinx size and location within the <span class="highlight">spinal</span>
cord may differ based on etiology or associated conditions of the brain
and spine. These differences have not been clearly defined. METHODS All
patients with a syrinx were identified from 14,118 patients undergoing
brain or cervical spine imaging at a single institution over an 11-year
interval. Syrinx width, length, and location in the <span class="highlight">spinal</span>
cord were recorded. Patients were grouped according to associated brain
and spine conditions including Chiari malformation Type I (CM-I),
secondary CM (2°CM), Chiari malformation Type 0 (CM-0), tethered cord,
other closed <span class="highlight">dysraphism</span>, and <span class="highlight">spinal</span> tumors. Syringes not associated with any known brain or <span class="highlight">spinal</span>
cord condition were considered idiopathic. Syrinx characteristics were
compared between groups. RESULTS A total of 271 patients with a syrinx
were identified. The most common associated condition was CM-I
(occurring in 117 patients [43.2%]), followed by <span class="highlight">spinal dysraphism</span>
(20 [7.4%]), tumor (15 [5.5%]), and tethered cord (13 [4.8%]).
Eighty-three patients (30.6%) did not have any associated condition of
the brain or <span class="highlight">spinal</span>
cord and their syringes were considered idiopathic. Syringes in
patients with CM-I were wide (7.8 ± 3.9 mm) compared with idiopathic
syringes (3.9 ± 1.0, p < 0.0001) and those associated with tethered
cord (4.2 ± 0.9, p < 0.01). When considering CM-I-associated and
idiopathic syringes, the authors found that CM-I-associated syringes
were more likely to have their cranial extent in the cervical spine
(88%), compared with idiopathic syringes (43%; p < 0.0001). The
combination of syrinx width greater than 5 mm and cranial extent in the
cervical spine had 99% specificity (95% CI 0.92-0.99) for
CM-I-associated syrinx. CONCLUSIONS Syrinx morphology differs according
to syrinx etiology. The combination of width greater than 5 mm and
cranial extent in the cervical spine is highly specific for
CM-I-associated syringes. This may have relevance when determining the
clinical significance of syringes in patients with low cerebellar tonsil
position.</div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com1tag:blogger.com,1999:blog-143552849494294388.post-19561750197241569272015-05-11T14:01:00.000-05:002015-05-11T14:01:16.670-05:00Sleep-disordered breathing in patients with myelomeningocele.<div class="title">
</div>
<div class="desc">
Patel DM, Rocque BG, Hopson B, Arynchyna A, Bishop ER, Lozano D, Blount JP. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25837889">Sleep-disordered breathing in patients with myelomeningocele.</a></div>
<span class="jrnl" title="Journal of neurosurgery. Pediatrics">J Neurosurg Pediatr</span>. 2015 Apr 3:1-6.<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
OBJECT
A paucity of literature examines sleep apnea in patients with
myelomeningocele, Chiari malformation Type II (CM-II), and related
hydrocephalus. Even less is known about the effect of hydrocephalus
treatment or CM-II decompression on sleep hygiene. This study is an
exploratory analysis of sleep-disordered breathing in patients with
myelomeningocele and the effects of neurosurgical treatments, in
particular CM-II decompression and hydrocephalus management, on sleep
organization. METHODS The authors performed a retrospective review of
all patients seen in their multidisciplinary <span class="highlight">spina bifida</span>
clinic (approximately 435 patients with myelomeningocele) to evaluate
polysomnographs obtained between March 1999 and July 2013. They analyzed
symptoms prompting evaluation, results, and recommended interventions
by using descriptive statistics. They also conducted a subset analysis
of 9 children who had undergone polysomnography both before and after
neurosurgical intervention. RESULTS Fifty-two patients had
polysomnographs available for review. Sleep apnea was diagnosed in 81%
of these patients. The most common presenting symptom was "breathing
difficulties" (18 cases [43%]). Mild sleep apnea was present in 26 cases
(50%), moderate in 10 (19%), and severe in 6 (12%). Among the 42
patients with abnormal sleep architecture, 30 had predominantly
obstructive apneas and 12 had predominantly central apneas. The most
common pulmonology-recommended intervention was adjustment of peripheral
oxygen supplementation (24 cases [57%]), followed by initiation of
peripheral oxygen (10 cases [24%]). In a subset analysis of 9 patients
who had sleep studies before and after neurosurgical intervention, there
was a trend toward a decrease in the mean number of respiratory events
(from 34.8 to 15.9, p = 0.098), obstructive events (from 14.7 to 13.9, p
= 0.85), and central events (from 20.1 to 2.25, p = 0.15) and in the
apnea-hypopnea index (from 5.05 to 2.03, p = 0.038, not significant when
corrected for multiple measures). CONCLUSIONS A large proportion of
patients with myelomeningocele who had undergone polysomnography showed
evidence of disordered sleep on an initial study. Furthermore, 31% of
patients had moderate or severe obstructive sleep apnea.
Myelomeningocele patients with an abnormal sleep structure who had
undergone nonoperative treatment with peripheral oxygen supplementation
showed improvement in the apnea-hypopnea index. Results in this study
suggested that polysomnography in patients with myelomeningocele may
present an opportunity to detect and classify sleep apnea, identify
low-risk interventions, and prevent future implications of
sleep-disordered breathing.</div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com1tag:blogger.com,1999:blog-143552849494294388.post-25876396070875483642015-05-11T13:59:00.003-05:002015-05-11T13:59:56.501-05:00Perception of secondary conditions in adults with spina bifida and impact on daily life.<span></span><br />
<div class="title">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/25958105"></a></div>
<div class="desc">
Wagner R, Linroth R, Gangl C, Mitchell N, Hall M, Cady R, Christenson M. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25958105">Perception of secondary conditions in adults with <b>spina bifida</b> and impact on daily life.</a></div>
<span class="jrnl" title="Disability and health journal">Disabil Health J</span>. 2015 Apr 4. pii: S1936-6574(15)00048-5. doi: 10.1016/j.dhjo.2015.03.012.<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
BACKGROUND: </h4>
<span class="highlight">Spina bifida</span> is a congenital defect of the neural tube resulting in motor and sensory disruption. Persons with <span class="highlight">spina bifida</span>
can also experience executive function impairments. Secondary
conditions are physical, medical, cognitive, emotional, or psychosocial
consequences to which persons with disabilities are more susceptible.
Our experience suggested clinicians underappreciate the presence and
impact of secondary conditions in adults with <span class="highlight">spina bifida</span> because they do not specifically ask for this information.<br />
<h4>
OBJECTIVE: </h4>
Describe the presence and impact of secondary conditions on daily life, as perceived by adults with <span class="highlight">spina bifida</span>.<br />
<h4>
METHODS: </h4>
A clinic-based sample was recruited from the active patient population of an adult specialty center for <span class="highlight">spina bifida</span>-related
care. All subjects were verbally administered a survey developed
through literature review and clinical experience of the researchers.
The survey measured the presence and perceived impact of secondary
conditions. Recruitment and survey data collection occurred over a
6-month period to maximize age representation. Survey data were
stratified by age, gender and lesion level for analysis.<br />
<h4>
RESULTS: </h4>
Seventy-two
respondents completed the survey. Pain was commonly reported, along
with pressure ulcers, bowel & bladder concerns, depression, sleep
disturbance, and limited social and community participation. No
significant relationships were found between the presence or perceived
impact of secondary conditions and age, gender or level of lesion.<br />
<h4>
CONCLUSIONS: </h4>
Secondary conditions in <span class="highlight">spina bifida</span>
are present by early adulthood. Identifying these conditions during
clinical encounters requires specific rather than general questions.
Future study should evaluate earlier initiation of preventative measures
by pediatric providers.<br />
Copyright © 2015 Elsevier Inc. All rights reserved.</div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-38935635184265720972015-05-11T13:58:00.003-05:002015-05-11T13:58:45.264-05:00Descriptive study on neural tube defects in Argentina.<span></span><br />
<div class="rslt">
<div class="title">
</div>
<div class="supp">
<div class="desc">
Sargiotto C, Bidondo MP, Liascovich R, Barbero P, Groisman B. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25855266">Descriptive study on neural tube defects in Argentina.</a></div>
<div class="details">
<span class="jrnl" title="Birth defects research. Part A, Clinical and molecular teratology">Birth Defects Res A Clin Mol Teratol</span>. 2015 Apr 8. doi: 10.1002/bdra.23372.</div>
<div class="details">
<br /></div>
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
BACKGROUND: </h4>
Neural
tube defects (NTDs) are the most common congenital anomalies of the
central nervous system. Prevalence of NTDs varies depending on
geographic region and folic acid fortification. The main objectives of
this study are to analyze the prevalences of NTDs reported to the
National Registry of Congenital Anomalies of Argentina (RENAC) during
the period 2009 to 2013, to compare them with data from other selected
surveillance systems of the Americas, and to evaluate the impact of
folic acid fortification on the prevalence of NTDs in Argentina.<br />
<h4>
METHODS: </h4>
We
analyzed changes in prevalence between 2009 and 2013 for the RENAC, and
differences in prevalence between RENAC and other surveillance systems.
We evaluated changes for the pre and postfortification time periods in
Argentina.<br />
<h4>
RESULTS: </h4>
In Argentina, anencephaly and <span class="highlight">spina bifida</span>
showed no statistically significant variation between 2009 and 2013,
and encephalocele showed a statistically significant decline. The RENAC
showed a statistically significant higher prevalence for all three
defects when compared with surveillance systems from Chile, Colombia,
and Costa Rica, and a statistically significant lower birth prevalence
than Cuba for anencephaly. No differences were observed when comparing
it to the Atlanta-USA and Mexico systems. A significant decrease in
prevalence was observed for all three anomalies for the
postfortification period in Argentina.<br />
<h4>
CONCLUSION: </h4>
The
characteristics of cases reported to the RENAC are similar to those
already reported in the literature. The differences in prevalence
between the RENAC and other surveillance systems could be artifactual or
real. We confirmed the decrease of prevalence of NTDs after folic acid
fortification. Birth Defects Research (Part A), 2015. © 2015 Wiley
Periodicals, Inc.<br />
© 2015 Wiley Periodicals, Inc.</div>
</div>
<div class="details">
<br /></div>
</div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-14345113515487820432015-05-11T13:57:00.000-05:002015-05-11T13:57:02.817-05:00Maternal consumption of non-staple food in the first trimester and risk of neural tube defects in offspring.<span></span><br />
<div class="title">
</div>
<div class="supp">
<div class="details">
Wang M, Wang ZP, Gao LJ, Yang H, Zhao ZT. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25919306">Maternal consumption of non-staple food in the first trimester and risk of neural tube defects in offspring.</a><span class="jrnl" title="Nutrients"> Nutrients</span>. 2015 Apr 24;7(5):3067-77. doi: 10.3390/nu7053067.</div>
<div class="details">
</div>
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
To
study the associations between maternal consumption of non-staple food
in the first trimester and risk of neural tube defects (NTDs) in
offspring. Data collected from a hospital-based case-control study
conducted between 2006 and 2008 in Shandong/Shanxi provinces including
459 mothers with NTDs-affected births and 459 mothers without
NTDs-affected births. Logistic regression models were used to examine
the associations between maternal consumption of non-staple food in the
first trimester and risk of NTDs in offspring. The effects were
evaluated by odds ratio (OR) and 95% confidence intervals (95% CIs) with
SAS9.1.3.software. Maternal consumption of milk, fresh fruits and nuts
in the first trimester were protective factors for total NTDs. Compared
with consumption frequency of ˂1 meal/week, the ORs for milk consumption
frequency of 1-2, 3-6, ≥7 meals/week were 0.50 (95% CI: 0.28-0.88),
0.56 (0.32-0.99), and 0.59 (0.38-0.90), respectively; the ORs for fresh
fruits consumption frequency of 1-2, 3-6, ≥7 meals/week were 0.29 (95%
CI: 0.12-0.72), 0.22 (0.09-0.53), and 0.32 (0.14-0.71), respectively;
the ORs for nuts consumption frequency of 1-2, 3-6, ≥7 meals/week were
0.60 (95% CI: 0.38-0.94), 0.49 (0.31-0.79), and 0.63 (0.36-1.08),
respectively. Different effects of above factors on NTDs were found for
subtypes of anencephaly and <span class="highlight">spina bifida</span>.
Maternal non-staple food consumption of milk, fresh fruits and nuts in
the first trimester was associated with reducing NTDs risk in offspring.
</div>
</div>
<div class="details">
<br /></div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-62989418712488539332015-05-11T13:55:00.003-05:002015-05-11T13:55:30.626-05:00Resilience and Disruption in Observed Family Interactions in Youth With and Without Spina Bifida: An Eight-Year, Five-Wave Longitudinal Study.<div class="desc">
Lennon JM, Murray CB, Bechtel CF, Holmbeck GN. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25914210">Resilience and Disruption in Observed Family Interactions in Youth With and Without <b>Spina Bifida</b>: An Eight-Year, Five-Wave Longitudinal Study.</a></div>
<span class="jrnl" title="Journal of pediatric psychology">J Pediatr Psychol</span>. 2015 Apr 24. pii: jsv033.<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
OBJECTIVE: </h4>
To examine differences between families of youth with <span class="highlight">spina bifida</span>
(SB) and families of typically developing (TD) youth on family-,
parent-, and youth-level variables across preadolescence and
adolescence. METHODS: Participants were 68 families of youth with SB
and 68 families of TD youth. Ratings of observed family interactions
were collected every 2 years at 5 time points (Time 1: ages 8-9 years;
Time 5: ages 16-17 years). RESULTS: For families of youth with SB:
families displayed less cohesion and more maternal psychological control
during preadolescence (ages 8-9 years); parents presented as more
united and displayed less dyadic conflict, and youth displayed less
conflict behavior during the transition to adolescence (ages 10-13
years); mothers displayed more behavioral control during middle (ages
14-15 years) and late (ages 16-17 years) adolescence; youth displayed
less engagement and more dependent behavior at every time point.
CONCLUSIONS: Findings highlight areas of resilience and disruption in
families of youth with SB across adolescence.<br />
© The
Author 2015. Published by Oxford University Press on behalf of the
Society of Pediatric Psychology. All rights reserved. For permissions,
please e-mail: journals.permissions@oup.com.</div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-75660539548798790332015-05-11T13:54:00.001-05:002015-05-11T13:54:23.159-05:00Arm cranking versus wheelchair propulsion for testing aerobic fitness in children with spina bifida who are wheelchair dependent.<span></span><br />
<div class="title">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/25882374"></a></div>
<div class="supp">
<div class="desc">
Bloemen MA, de Groot JF, Backx FJ, Westerveld RA, Takken T. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25882374">Arm cranking versus wheelchair propulsion for testing aerobic fitness in children with <b>spina bifida</b> who are wheelchair dependent.</a></div>
<div class="details">
<span class="jrnl" title="Journal of rehabilitation medicine">J Rehabil Med</span>. 2015 Apr 28;47(5):432-7. doi: 10.2340/16501977-1944.</div>
<div class="details">
<br /></div>
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
OBJECTIVE: </h4>
To
determine the best test performance and feasibility using a Graded Arm
Cranking Test vs a Graded Wheelchair Propulsion Test in young people
with <span class="highlight">spina bifida</span> who use a wheelchair, and to determine the reliability of the best test.<br />
<h4>
DESIGN: </h4>
Validity and reliability study.<br />
<h4>
SUBJECTS: </h4>
Young people with <span class="highlight">spina bifida</span> who use a wheelchair.<br />
<h4>
METHODS: </h4>
Physiological
responses were measured during a Graded Arm Cranking Test and a Graded
Wheelchair Propulsion Test using a heart rate monitor and calibrated
mobile gas analysis system (Cortex Metamax). For validity, peak oxygen
uptake (VO2peak) and peak heart rate (HRpeak) were compared using paired
t-tests. For reliability, the intra-class correlation coefficients,
standard error of measurement, and standard detectable change were
calculated.<br />
<h4>
RESULTS: </h4>
VO2peak
and HRpeak were higher during wheelchair propulsion compared with arm
cranking (23.1 vs 19.5 ml/kg/min, p = 0.11; 165 vs 150 beats/min,
p < 0.05). Reliability of wheelchair propulsion showed high
intra-class correlation coefficients (ICCs) for both VO2peak
(ICC = 0.93) and HRpeak (ICC = 0.90).<br />
<h4>
CONCLUSION: </h4>
This pilot study shows higher HRpeak and a tendency to higher VO2peak in young people with <span class="highlight">spina bifida</span>
who are using a wheelchair when tested during wheelchair propulsion
compared with arm cranking. Wheelchair propulsion showed good
reliability. We recommend performing a wheelchair propulsion test for
aerobic fitness testing in this population.</div>
</div>
<div class="details">
<br /></div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-83792127005340390192015-05-11T13:53:00.000-05:002015-05-11T13:53:09.283-05:00Urinary incontinence in spina bifida: Initial instrument validation.<div class="title">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/25841183"></a></div>
<div class="desc">
Hubert KC, Sideridis G, Sherlock R, Rosoklija I, Kringle G, Johnson K, Bauer SB, Nelson CP.</div>
<span class="jrnl" title="Research in developmental disabilities">(2015) </span><span class="jrnl" title="Research in developmental disabilities"><a href="http://www.ncbi.nlm.nih.gov/pubmed/25841183">Urinary incontinence in <b>spina bifida</b>: Initial instrument validation.</a> Res Dev Disabil</span>. 2015 May;40:42-50. doi: 10.1016/j.ridd.2015.01.008.<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
The
purpose of this study was to perform a psychometric assessment of the
Incontinence Symptom Index-Pediatric (ISI-P) in a cohort of adolescents
with <span class="highlight">spina bifida</span>
(SB) and neuropathic urinary incontinence (UI) to test its validity and
reliability. The ISI-P, an 11-item instrument with domains for symptom
severity and impairment, was self-administered by subjects 11-17 years
old with SB and UI. Controls were 11-17 years old, with nephrolithiasis
and no history of UI. Formal psychometric assessment included an
evaluation of internal consistency, test re-test reliability and factor
analysis. Of 78 study-eligible subjects we attempted to contact, 33
(66.7% female) with a median age of 13.1 years completed the ISI-P
(42.3% response rate). 21 control patients also completed the ISI-P.
Cronbach's alpha was 0.936 and 0.792 for the severity and bother factors
respectively. The delta Chi-square test for the two-factor (vs.
one-factor) model was significantly [χ(2)(89)=107.823, p<0 .05="" adolescents="" all="" analysis="" and="" associated="" being="" categories="" category="" comparative="" conclusion="" contributed="" descriptive="" desirable="" different="" e.g.="" each="" excellent="" favor="" fit="" for="" former="" furthermore="" has="" impairment="" in="" index="0.969)." indices="" information="" isi-p="" latent="" measurement="" model="" namely="" of="" p="" properties="" psychometric="" sb.="" severity="" showed="" symptom="" that="" the="" threshold="" trait.="" ui="" unique="" values="" were="" with="">Copyright © 2015 Elsevier Ltd. All rights reserved.</0></div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-85829232552410872562015-05-11T13:52:00.000-05:002015-05-11T13:52:01.650-05:00An increase in spina bifida cases in Tunisia, 2008-2011.<span></span><br />
<div class="title">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/25617140"></a></div>
<div class="desc">
Nasri K, Ben Fradj MK, Aloui M, Ben Jemaa N, Masmoudi A, Elmay MV, Marrakchi R, Siala Gaigi S. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25617140">An increase in <b>spina bifida</b> cases in Tunisia, 2008-2011.</a></div>
<span class="jrnl" title="Pathology, research and practice">Pathol Res Pract</span>. 2015 May;211(5):369-73. doi: 10.1016/j.prp.2014.12.011<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
BACKGROUND: </h4>
The term <span class="highlight">spina bifida</span> refers to a group of neural tube defects that result in malformations of the <span class="highlight">spinal</span> cord and the surrounding vertebrae. Though the etiologies of <span class="highlight">spina bifida</span> remain largely unknown, several risk factors have been identified, including feto-maternal characteristics.<br />
<h4>
AIM OF THE STUDY: </h4>
To discover possible underlying reasons for the increase of <span class="highlight">spina bifida</span> and identify intervention targets, an investigation was undertaken comparing <span class="highlight">spina bifida</span>-affected pregnancy notifications in 2008-2011 with notifications in the period 1991-1994.<br />
<h4>
METHODS: </h4>
Characteristics and outcomes of births with <span class="highlight">spina bifida</span> and pregnancy characteristics of mothers were recorded in the medical chart. Comparisons of pregnancies affected by a <span class="highlight">spina bifida</span> in 2008-2011 were made with pregnancies affected by a <span class="highlight">spina bifida</span> in the period 1991-1994. Statistical analysis was undertaken using Poisson regression and Chi-squared tests.<br />
<h4>
RESULTS: </h4>
From 1991 through 1994, the prevalence of identified <span class="highlight">spina bifida</span>
cases was equal to 0.3/10,000 births compared to 1.6/10,000 births in
2008-2011. This increase was statistically significant (P<0 .001="" 0.16="" 0.45="" 1.88="" 10="" 1991-1994="" 2008-2011.="" 30="" a="" age="" as="" between="" births="" both="" class="highlight" compared="" difference="" during="" emergence="" equal="" females="" for="" genders.="" had="" impact="" in="" males="" mother="" of="" on="" over="" per="" period="" prevalence="" s="" significant="" span="" statistically="" the="" to="" was="" years="">spina bifida</0></div>
</div>
(P=0.02, OR=3.93, CI=1.23-12.47). As well as, maternal blood type was a significant risk factor for the appearance of <span class="highlight">spina bifida</span>
(P=0.008). Results also had shown that fetal weight and term, gestity
and parity were significant risk factors for the occurrence of <span class="highlight">spina bifida</span> (P<0 .05="" adjusted.="" analyses="" been="" being="" caution="" due="" have="" interpreted="" n="" not="" p="" results="" study="" this="" to="" with=""><h4>
CONCLUSION: </h4>
This analysis highlighted areas where prevention efforts should be strengthened and surveillance data improved.<br />
Copyright © 2014 Elsevier GmbH. All rights reserved.</0>lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-51828076684216024242015-05-11T13:50:00.001-05:002015-05-11T13:50:23.529-05:00A longitudinal examination of health-related quality of life in children and adolescents with spina bifida.<div class="title">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/25434043"></a></div>
<div class="desc">
Murray CB, Holmbeck GN, Ros AM, Flores DM, Mir SA, Varni JW. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25434043">A longitudinal examination of health-related quality of life in children and adolescents with <b>spina bifida</b>.</a></div>
<span class="jrnl" title="Journal of pediatric psychology">J Pediatr Psychol</span>. 2015 May;40(4):419-30. doi: 10.1093/jpepsy/jsu098<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
OBJECTIVE: </h4>
The current study examined (1) <span class="highlight">spina bifida</span>
(SB) youths' health-related quality of life (HRQOL) compared with
nonclinical and chronic health condition (CHC) samples, (2) parent-child
agreement regarding HRQOL, and (3) prospective changes in HRQOL. <br />
<h4>
METHODS: </h4>
Child and parent-proxy reports of Pediatric Quality of Life were
collected at two time waves (Time 1: N = 134, ages 8-15 years; Time 2: N
= 109, ages 10-17 years) as part of a larger longitudinal study. <br />
<h4>
RESULTS: </h4>
SB youth had statistically and clinically reduced physical HRQOL
compared with the nonclinical and CHC samples at both time points. There
were significant discrepancies between youth and parent-proxy reports
of HRQOL; youth reported higher levels of physical and social HRQOL than
parents. The majority of parent- and child-reported HRQOL domains
remained stable, yet youth-reported social HRQOL increased over time. <br />
<h4>
CONCLUSIONS: </h4>
Youth with SB are at risk for poor HRQOL. Examining modifiable condition
and social-environmental predictors of youth HRQOL will be important in
informing future interventions.<br />
© The Author 2014.
Published by Oxford University Press on behalf of the Society of
Pediatric Psychology. All rights reserved. For permissions, please
e-mail: journals.permissions@oup.com.</div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-57315058570467225462015-05-11T13:49:00.001-05:002015-05-11T13:49:13.155-05:00Early outcome of combined endoscopic third ventriculostomy and choroid plexus cauterization in childhood hydrocephalus.<div class="title">
<br /></div>
<div class="desc">
Bankole OB, Ojo OA, Nnadi MN, Kanu OO, Olatosi JO. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25679383">Early outcome of combined endoscopic third ventriculostomy and choroid plexus cauterization in childhood hydrocephalus.</a></div>
<span class="jrnl" title="Journal of neurosurgery. Pediatrics">J Neurosurg Pediatr</span>. 2015 May;15(5):524-8. doi: 10.3171/2014.10.PEDS14228<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
OBJECT
Although shunts have been the mainstay in treating hydrocephalus over
the past 5 decades, the use of endoscopic techniques in addressing this
disorder in children offers both the neurosurgeon and the patient a
unique opportunity to avoid shunting and its attendant complications.
The combination of endoscopic third ventriculostomy (ETV) with choroid
plexus cauterization (CPC) remains uncommon in most centers despite its
potential promise. The authors sought to investigate the efficacy of
combining ETV and CPC (ETV+CPC) in treating childhood hydrocephalus in
Nigeria. Infection and <span class="highlight">spina bifida</span>
contribute a high percentage of the cases of hydrocephalus in Nigeria.
METHODS Over a 2-year period, all children 0-18 years of age who had
endoscopic treatment for hydrocephalus were prospectively evaluated to
determine the need for subsequent treatment. Children who had the
combination of ETV+CPC were identified as a subcategory and form the
basis of this retrospective study. RESULTS Twenty-two of 38
endoscopically treated children had undergone the combination of ETV+CPC
for hydrocephalus of varied etiology. There was a male preponderance
(2.5:1), and 90% of the patients were infants. The overall success rate
was 75%, with the best outcome in children with <span class="highlight">spina bifida</span>.
One child required a repeat ETV. CONCLUSIONS The combination of ETV+CPC
is useful in treating children with hydrocephalus of varied etiology.
The complication profile is acceptable, and the overall success rate is
comparable to that associated with shunt insertion. </div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-85758492516661125942015-05-11T13:48:00.000-05:002015-05-11T13:48:00.991-05:00Risk of fracture prevention in spina bifida patients: correlation between bone mineral density, vitamin D, and electrolyte values.<div class="desc">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/25930725">Risk of fracture prevention in <b>spina bifida</b> patients: correlation between bone mineral density, vitamin D, and electrolyte values.</a> (2015) Martinelli V, Dell'Atti C, Ausili E, Federici E, Magarelli N, Leone A, Massimi L, Di Rocco C, Bonomo L, Rendeli C.</div>
<span class="jrnl" title="Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery">Childs Nerv Syst</span>. 2015 May 1.<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
PURPOSE: </h4>
The
aim of our study was to investigate the relationship between bone
mineral density (BMD), vitamin D, and electrolyte blood values in
patients with <span class="highlight">spina bifida</span>, to find a possible therapeutic regimen and an intervention to reduce the risk of fractures in this population.<br />
<h4>
METHODS: </h4>
BMD
values were measured in 49 patients (32 females, 17 males; aged
14.1 ± 3.86 years; range 5-20 years) using dual-energy X-ray
absorptiometry (DEXA) and were analyzed based on sex, the level of <span class="highlight">spinal</span>
involvement, vitamin D, and electrolyte values, physical activity, body
mass index (BMI), and ambulatory status [patients were divided into
three subgroups: full-time wheelchair (FTWC), limited ambulator (LA),
and full-time ambulator (FTA)]. These data were analyzed considering
sex-, age-, and BMD-matched values and compared with those of normal
population.<br />
<h4>
RESULTS: </h4>
BMD
was significantly lower in these patients compared with that in the
general healthy population (Z-score: -1.2 ± 1.8); in particular, females
had Z-score values significantly lower that of the males (Z-score:
-2.43 ± 2.02; P < 0.0004). In FTWC subgroup, Z-score was lower than
that of the other two subgroups (P < 0.009). Vitamin D values were
significantly lower compared with those in the general healthy
population (vitamin D <span class="highlight">spina bifida</span> group: 14.6 ± 8.7 mg/dL; normal subjects: 35 ± 9.8 mg/dL; P < 0.001). Subjects with <span class="highlight">spina bifida</span> showed hypophosphatemia (<3 0.001="" 0.9="" because="" d="" dl="" levels="" lower="" mg="" nbsp="" of="" p="" the="" vitamin=""><h4>
CONCLUSIONS: </h4>
<span class="highlight">Spina bifida</span>
patients showed lower BMD, vitamin D, and electrolyte values than the
healthy population; hence, they have an increase risk of developing
pathological fractures. Vitamin D supplementation for a longer time
period could reduce this risk.</3></div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-87240554499602277522015-05-11T13:46:00.000-05:002015-05-11T13:46:23.062-05:00Past and current use of walking measures for children with spina bifida: a systematic review.<div class="title">
<a href="http://www.ncbi.nlm.nih.gov/pubmed/25944500"></a></div>
<div class="desc">
Bisaro DL, Bidonde J, Kane KJ, Bergsma SA, Musselman KE. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25944500">Past and current use of walking measures for children with <b>spina bifida</b>: a systematic review.</a></div>
<span class="jrnl" title="Archives of physical medicine and rehabilitation">Arch Phys Med Rehabil</span>. 2015 May 2. pii: S0003-9993(15)00384-6. doi: 10.1016/j.apmr.2015.04.014<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
OBJECTIVE: </h4>
To describe walking measurement in children with <span class="highlight">spina bifida</span>, and to identify patterns in the use of walking measures in this population.<br />
<h4>
DATA SOURCES: </h4>
Seven medical databases were searched from inception until March 2014. Search terms encompassed three themes: 1) children, 2) <span class="highlight">spina bifida</span>, and 3) walking.<br />
<h4>
STUDY SELECTION: </h4>
Articles were included if participants were children aged 1-17 years with <span class="highlight">spina bifida</span>,
and if walking was measured. Articles were excluded if the assessment
was restricted to kinematic, kinetic or electromyographic analyses of
walking. A total of 1,751 abstracts were screened by two authors
independently, and 109 articles were included in this review.<br />
<h4>
DATA EXTRACTION: </h4>
Data
were extracted using standardized forms. Extracted data included study
and participant characteristics, and details about the walking measures
used, including psychometric properties. Two authors evaluated the
methodological quality of articles using a previously published
framework that considers sampling method, study design, and psychometric
properties of the measures used.<br />
<h4>
DATA SYNTHESIS: </h4>
Nineteen
walking measures were identified. Ordinal-level rating scales (e.g.,
Hoffer Functional Ambulation Scale) were most commonly used (57% of
articles), followed by ratio-level, spatiotemporal measures, such
walking speed (18% of articles). Walking was measured for a variety of
reasons relevant to multiple health care disciplines. A machine learning
analysis was used to identify patterns in the use of walking measures.
The learned classifier predicted whether or not a spatiotemporal measure
was used with 77.1% accuracy. A trend to use spatiotemporal measures in
older children and those with lumbar and sacral <span class="highlight">spinal</span>
lesions was identified. Most articles were prospective studies that
used samples of convenience and unblinded assessors. Few articles
evaluated or considered the psychometric properties of the walking
measures.<br />
<h4>
CONCLUSIONS: </h4>
Despite a demonstrated need to measure walking in children with <span class="highlight">spina bifida</span>, few valid, reliable and responsive measures have been established for this population.<br />
Copyright © 2015 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.</div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-48523343198222776822015-05-11T13:44:00.003-05:002015-05-11T13:44:58.565-05:00The Severity of Bowel Dysfunction in Patients with Neurogenic Bladder.<div class="title">
</div>
<div class="desc">
Cameron AP, Rodriguez GM, Gursky A, He C, Clemens JQ, Stoffel JT. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/25956470">The Severity of Bowel Dysfunction in Patients with Neurogenic Bladder.</a></div>
<span class="jrnl" title="The Journal of urology">J Urol</span>. 2015 May 5. pii: S0022-5347(15)03905-1. doi: 10.1016/j.juro.2015.04.100<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
PURPOSE: </h4>
Patients
with neurological conditions often suffer from severe debilitating
lower urinary and bowel dysfunction in addition to their physical
disabilities. However, only the bladder has received the attention of
medical providers with neurogenic bowel being poorly understood and
characterized.<br />
<h4>
MATERIALS AND METHODS: </h4>
This is a cross-sectional analysis of a prospective institutional Neurogenic Bladder Database from 2010-2013.<br />
<h4>
RESULTS: </h4>
Among the 175 patients 60.6% had traumatic <span class="highlight">spinal</span>
cord injury (SCI) and 18.3% multiple sclerosis. Fecal Incontinence
Severity Index (FISI) scores were a median of 18.0±1.39 (moderate).
Neurogenic Bowel Dysfunction (NBD) score were a median of 11.0±0.63
(moderate). NBD Scores were worse in those patients with SCI and <span class="highlight">spina bifida</span>
compared to other diseases (P=0.020), in younger patients (p=0.020) and
in the SCI group those with higher levels of injury (p=0.0046). Based
on the Bristol stool scale 65% of patient had abnormal stool
consistency, mostly constipation. None of the FISI, Bristol or NBD
scores correlated significantly with SF-12 quality of life measures.
However, both of the bladder symptom scores Michigan Incontinence
Symptom Index (M-ISI)(p=0.05) and the AUA-SI (p=0.03) correlated with
FISI severity and the NBD score correlated with the M-ISI (ρ=0.29,
p=0.02). Those patients with abnormal stool consistency on the Bristol
reported more urgency and stress incontinence on M-ISI.<br />
<h4>
CONCLUSIONS: </h4>
Bowel
dysfunction is very common among patients with neurogenic bladder.
Those patients with worse bladder symptoms also suffered from worse
bowel dysfunction. This highlights the importance of addressing both
bowel and bladder dysfunction in this often poorly understood
population.<br />
Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.</div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0tag:blogger.com,1999:blog-143552849494294388.post-68132141416337858542015-05-11T13:43:00.003-05:002015-05-11T13:43:43.600-05:00Examination of the relationship between body mass index (BMI) and functional independence level in children with spina bifida.<div class="desc">
Şimşek TT, Türkücüoğlu B, Tezcan S. (2015) <a href="http://www.ncbi.nlm.nih.gov/pubmed/23869723">Examination of the relationship between body mass index (BMI) and functional independence level in children with <b>spina bifida</b>.</a></div>
<span class="jrnl" title="Developmental neurorehabilitation">Dev Neurorehabil</span>. 2015 Jun;18(3):149-54. doi: 10.3109/17518423.2013.796419<br />
<br />
<div class="abstr">
<h3>
Abstract</h3>
<div class="">
<h4>
OBJECTIVE: </h4>
The
aim of this study is to examine the relationship between body mass
index (BMI) and functional independence level in children with <span class="highlight">spina bifida</span> (SB).<br />
<h4>
METHODS: </h4>
The
study included 116 children between 5 and 18 years. Subjects'
socio-demographic characteristics, BMI values and functional
independence levels were recorded.<br />
<h4>
RESULTS: </h4>
There
was negative correlation between BMI and communication and social
cognition in girls (p < 0.05). No correlation was found between BMI
and WeeFIM in boys (p > 0.05).<br />
<h4>
CONCLUSION: </h4>
The
results indicated that body weight in children with SB affected
functional independency and that precautions to control weight important
in these children.</div>
</div>
lindahttp://www.blogger.com/profile/03731622853034675340noreply@blogger.com0